Uehling, J. et al, 2017. PLoS Pathogens Pearls

Do fungi have an innate immune response?  An NLR-based comparison to plant and animal immune systems.

Jessie Uehling, Aurélie Deveau and Mathieu Paoletti
26 October 2017, PLoS Pathogens 13(10):  e1006578; doi: 10.1371/journal.ppat.1006578


Survival and evolutionary success of living organisms directly depend on the ability to respond appropriately to their biotic environments.  Plants and animals have developed intricate mechanisms of recognition and response that require differentiation between self and potentially pathogenic nonself and containment of infected tissues.  A class of cytosolic Nucleotide Oligomerization Domain (NOD)-like receptors, or NLRs, contribute to this recognition and discrimination process in plants and animals.  Less is known about how fungi monitor their interactions with their biotic environments.  Here, we summarize evidence indicating that fungi have similar NLR proteins and may use similar mechanisms to recognize and respond to heterospecific nonself; we outline similarities and differences with their plant and animal counterparts, and we propose future directions elucidating aspects of fungal immune systems


Uehling J, Deveau A, Paoletti M (2017) Do fungi have an innate immune response? An NLR-based comparison to plant and animal immune systems. PLoS Pathogens 13(10): e1006578.

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