Attacking the opioid epidemic: Determining the epistatic and pleiotropic genetic architectures for chronic pain and opioid addiction
Wayne Joubert, Deborah Weighill, David Kainer, Sharlee Climer, Amy Justice, Kjiersten Fagnan, Daniel Jacobson
11 Nov 2018, SC’18 Proceedings of the International Conference for High Performance Computing, Networking, Storage, and Analysis, Article 57; pages 1-14; https://doi.org/10.1109/SC.2018.00060
We describe the CoMet application for largescale epistatic Genome-Wide Association Studies (eGWAS) and pleiotropy studies. High performance is attained by transforming the underlying vector comparison methods into highly performant generalized distributed dense linear algebra operations. The 2-way and 3-way Proportional Similarity metric and Custom Correlation Coefficient are implemented using native or adapted GEMM kernels optimized for GPU architectures. By aggressive overlapping of communications, transfers and computations, high efficiency with respect to single GPU kernel performance is maintained up to the full Titan and Summit systems. Nearly 300 quadrillion element comparisons per second and over 2.3 mixed precision ExaOps are reached on Summit by use of Tensor Core hardware on the Nvidia Volta GPUs. Performance is four to five orders of magnitude beyond comparable state of the art. CoMet is currently being used in projects ranging from bioenergy to clinical genomics, including for the genetics of chronic pain and opioid addiction.
Joubert, W., Weighill, D., Kainer, D., climes, S., Justice, A., Fagnan, K., and Jacobson, D. 2018. Attacking the opioid epidemic: determine the epistatic and pleiotropic genetic architectures for chronic pain and opioid addiction. Proceedings of the International Conference for High Performance Computing, Networking, Storage, and Analysis; Dallas, TX November 2018.